ea0092op-05-05 | Oral Session 5: Young Investigators / Basic | ETA2023
Hoppe Christoph
, Sebastian Hones G.
, Siemes Devon
, Wenzek Christina
, Flamant Frederic
, Gauthier Karine
, Engel Daniel R.
, Zwanziger Denise
, Lange Christian M.
, Baba Hideo
, Fuhrer-Sakel Dagmar
, Christian Moller Lars
Thyroid hormones (TH) reduce liver steatosis. As steatosis is the initial step of alcoholic liver disease (ALD), we hypothesized that TH treatment could ameliorate ALD. Wildtype (WT) mice were treated with either ethanol (EtOH) or liquid control diet for 10 days followed by a single EtOH or maltose binge on day 11. In both groups, diet was supplemented with either T3 or solvent. Serum triglycerides (TG) were increased by EtOH and, surprisingly, further elevated by T3. Liver we...